SME News Q1 2025 / 6 The gap between new science and new medicine is vast. Each year, 3 million biomedical studies are published, yet only 46 new drugs approved - often close cousins of existing ones. So do we need more science, for more medicine or a better way to transform what we have into improved clinical outcomes? UPmedicine TI If we step back and examine the immense redundancy in science, it’s clear we need science to be ‘more productive.’ But what would that actually require? • A radical rethink of the very essence and principles of medicine. • The power to transform fragmented discoveries into cohesive new knowledge, re-envisioning the status quo to breach new frontiers. • Intricate, encyclopaedic mapping of the ‘blueprint’ constitution and composition of the human being. As complex interconnected and dynamic systems. • A revolution in how we understand disease, health, and individual variation. • And crucially, a new ‘intelligence’ – capable of translating radical new vision, thought, knowledge, understanding, insights, maps, and science, into impactful treatments and meaningful clinical breakthroughs. Which, in outcome, chunks up to a fundamental New Medicine generated to unlock the full potential of all scientific discovery. That’s a lot! So let’s unpack this… When Medicine Doesn’t Have All the Answers Medicine has advanced so much that we often expect doctors to fix what ails us. But sometimes, we hit a roadblock. There’s little or nothing that can be done. It’s easy to think science hasn’t found a solution for our condition, but is that really the case? Rethinking How We Overcome Medical Hurdles If the vast reservoir of scientific knowledge doesn’t fall short, then perhaps the problem lies in how we approach it. What’s needed isn’t more research but a rethinking of how we transform existing science into actionable solutions. It’s not a lack of answers – it’s a failure to unlock them. Beyond Simplistic Models in Medicine Treatment ceilings may not be inevitable; they often result from trying to solve complex health problems with narrow outdated assumptions. Imagine focusing solely on the ball while ignoring the team that co-ordinates to direct it. Medicine thrives on understanding and working with the full picture. The challenge is how to approach this. Embracing Dynamic Systems for Health Solutions Rather than clinging to the false notion of a single cause for a condition and a linear solution to fix it, we need a new intelligence capable of grappling with complex problems involving ever-shifting, inter-connected bio-systems. Given we categorically now know countless factors are involved in every disease. Personalized Targets for Individual Needs What if this intelligence could identify which factors – from thousands, millions – are the most significant targets for each affected person, considering the uniquenesses of their makeup and biography? Since everyone has their own mix of relevant variables, different from someone else with the same condition. Meet Revolutionary Innovators: UPmedicine TI Founded by Dr. Alex Concorde, a multi-awardwinning inovator in medicine and science, and Oonah Buist, a strategic progression conceptualizer, UPmedicine TI is revolutionizing the landscape of clinical research. At its core lies Translational Intelligence® (TI) – a framework of solution-driven ‘brainpower’ designed to propel medical science into outputs for clinical gains. A New Approach for Achieving the Unexpected UPmedicine TI is redefining how therapeutic advancements are pursued, challenging conventional dogma in areas where progress has stalled despite an overwhelming body of science. It offers a radically different approach. Initially designed to tackle conditions that elude conventional medicine – such as rare diseases, refractory cases, and extraordinary presentations – UPmedicine TI’s engine is demonstrably relevant to virtually any health issue, looking for ‘unexpected gains’ from the variables of each individual. As Dr. Alex Concorde notes, “The gains we aim to achieve are ‘unexpected’ because they fall outside the normal modus of ‘conceptualization’. We venture beyond the edges of conventional thought patterns. If we stayed within them, there would be no gains. If you keep doing what’s always been done, you’ll only get what you’ve always got.” Maximizing the Use of Existing Science Through New Knowledge "We wondered whether, for any desired outcome, we could create a clinical edge by fundamentally rethinking the problem’s composition through all available science. For that you must ‘rise above’ it - it’s not enough to throw every piece of science at the issue. Recognized Leader in Translational Medicine R&D – UK Dec23345
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